Exposure-Based Developmental Toxicity Prediction with the devTOX quickPredict Assay – Webinar (2017) [Recording, Slides]
The required in vivo preclinical models for developmental toxicity testing have varying degrees of concordance with human effects, having approximately 70% concordance to known human developmental toxins. Development and validation of alternative methods for assessing developmental toxicity potential, such as the devTOX quickPredict assay (devTOXqP) would decrease the time, expense, and use of vertebrate animals. Previous approaches for evaluating the accuracy of these alternative test methods have been based on the classification of a chemical as a positive or negative, which does not mimic the in vivo situation, where a chemical is positive or negative in the context of dose level. The devTOXqP assay was designed around the premise that manifestation of developmental toxicity is dependent to a large degree on chemical dose. The Developmental and Reproductive Toxicology Technical Committee of the ILSI Health and Environmental Sciences Institute has published a list of positive and negative developmental exposures, with exposure defined by toxicokinetic data, specifically maternal plasma Cmax (Daston et al., 2014). We have tested this list of chemicals and exposures with the devTOXqP assay and will present the results in this webinar.
Beth Donley, CEO,
Jessica Palmer, Associate Director, Toxicology