Human In Vitro Developmental Toxicity Assay Combined with a Read-Across Approach for Chemical Assessment [ASCCT 2018 – PDF]
Human In Vitro Developmental Toxicity Assay Combined with a Read-Across Approach for Chemical Assessment
Presented at the American Society for Cellular and Computational Toxicology; September 2018
The reproductive and developmental toxicity requirements for registering chemical substances under REACH (Registration, Evaluation, Authorization, and Restriction of Chemicals) using whole-animal models could cost up to $8 billion and require the use of up to 22 million animals. However, the law encourages the use of alternative methods such as in vitro assays and structure-activity relationship (SAR) methods for addressing data gaps and requires authorization for animal testing from the European Chemicals Agency (ECHA). In this study, we illustrate how an in vitro assay can be used to strengthen and enhance the read across and weight of evidences approaches used in preparation of REACH dossiers.