Accurate, sensitive, and specific results
devTOX quickPredictTM ACCURATELY PREDICTS HUMAN RESPONSE
devTOX quickPredictTM is as predictive of human toxicity as the required in vivo tests and more predictive than other alternative assays.
Model System | Number of Compounds | Model Accuracy** | devTOX qP TM Accuracy** |
---|---|---|---|
Rodent* | 35 | 86% | 89% |
Rabbit* | 28 | 79% | 86% |
Mouse EST | 23 | 74% | 91% |
Zebrafish | 24 | 75% | 92% |
Whole Embryo Culture | 26 | 73% | 96% |
All values based on literature review of other systems and known / suspected human developmental toxicants.
*Current required in vivo tests
**Assay accuracy compared to suspected human developmental toxicity potential
devTOX quickPredictTM Results Interpretation
- Toxicity is a function of exposure
- Identify exposure level that alters metabolism
- Developmental Toxicity Threshold: Level of change in O/C ratio associated with developmental toxicity.
- Developmental Toxicity Potential: Test compound concentration predicted to be associated with developmental toxicity.
- Changes in the O/C ratio can be compared to cell viability.
- Determine non-toxic and toxic exposure windows
Why devTOX quickPredictTM
Flexibility
Choose undifferentiated human embryonic stem (hES) cells or induced pluripotent stem (iPS) cells.
Sensitivity and Selectivity
The assay is performed using cells exposed to eight different concentrations of each test article, which offers a broader look at developmental toxicity potential.
Assay Validation
Our assay has been internally validated with more than 80 compounds with published human / in vivo developmental toxicity data.
How it Works
SUBMIT SAMPLES FOR TESTING WITH THE SAMPLE SUBMISSION FORM
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