Cardio quickPredict: A New Way to Evaluate Cardiotoxicity Potential – SOT 2018 [Presentation Slides – PDF]
Presented at the Society of Toxicology Annual Meeting and ToxEXPO in San Antonio, Texas, March 2018 by Stemina’s Associate Director of Toxicology, Jessica Palmer.
Predicting cardiotoxicity remains a challenge. Cardiovascular toxicity is a major cause leading to compound attrition throughout the drug discovery and development process as well as withdrawal of FDA-approved drugs from the market. The Cardio quickPredict assay classified the training and tests sets with a combined accuracy of 84% across 78 compounds. When combined with other assays or endpoints, Cardio quickPredict can give a comprehensive understanding of a compound’s cardiotoxic liability.