Our new cardiotoxicity assay, Cardio quickPredict, is now available. The assay indicates the cardiotoxicity potential of drug candidates and other lead compounds, based on changes in human induced pluripotent stem cell-derived cardiomyocyte (iPSC-CM) metabolism and viability.
Cardio quickPredict provides an indication of cardiotoxicity and identifies functional or structural cardiotoxicants with a single assay. We plan to offer electrophysiological and non-cardiomyocyte viability endpoints in the future. Stay tuned!
In a recent study, we exposed iPSC-derived cardiomyocytes to 78 compounds and analyzed the spent media using UPLC-HRMS-based metabolomics. Cardiotoxicity potential was predicted based on changes in four metabolites and cell viability. (For full details, view the poster.)
Cardio quickPredict Model is 84% Predictive of Carditoxicity
Read our Cardio quickPredict brochure for more information.
CardioqP uses iCell® Cardiomyocytes2: Watch this video of beating iCell® Cardiomyocytes courtesy of Cellular Dynamics International, a FUJIFILM company.