Gina Wentling   Posted in News    Oct 25th, 2017

Stemina to Present a Poster at American College of Toxicology Annual Meeting

Jessica Palmer, Stemina’s Associate Director of Toxicology, will present a poster at the American College of Toxicology’s 38th Annual Meeting, held November 5-8, 2017 in Palm Springs, California. Anyone interested in cardiotoxicity assays is encouraged to attend.

Development of a Targeted Biomarker Assay to Predict Cardiotoxicity Potential Using Metabolomics and Human Induced Stem Cell-Derived Cardiomyocytes
Monday, 11/6 | 5:30 – 7:00 PM | Poster P530

About the poster
Cardiac safety is one of the leading causes of late-stage compound attrition in the pharmaceutical industry and accounts for 28% of the safety related withdrawals of FDA-approved drugs from the market. The current safety testing methods overemphasize electrophysiological assessment of cardiotoxicity and fail to evaluate cardiomyopathy and other forms of structural cardiotoxicity.

Stemina has developed a biomarker-based assay for evaluating the cardiotoxicity potential of compounds based on changes in the metabolic signature of human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes.