Presentations

Nov 8

Development of a Targeted Biomarker Assay to Predict Cardiotoxicity Potential Using Metabolomics and Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes – ACT 2017

Nov 8, 2017
Presented at the American College of Toxicology’s 38th Annual Meeting in Palm Springs, California in November 2017 by Stemina’s Associate Director of Toxicology, Jessica Palmer. Cardiac safety is one of the leading causes of late-stage compound attrition in the pharmaceutical industry and accounts for 28% of the safety related withdrawals of FDA-approved drugs from the

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Oct 4

Developmental Toxicity Potency of Valproate Analogues in a Human Pluripotent Stem Cell-Based Assay – Northland Chapter of SOT (2017) [Slides]

Oct 4, 2017
Developmental Toxicity Potency of Valproate Analogues in a Human Pluripotent Stem Cell-Based Assay Presented at the Annual Meeting of the Northland Chapter of the Society of Toxicology (September 2017) by Jessica Palmer, Associate Director of Toxicology Development and validation of alternative models for developmental toxicity testing is essential for reducing the number of animals used

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Aug 16

Utilizing devTOXqP in a Combined Testing Approach for Identifying Developmental Toxicity Liability of Chemicals – Webinar (2017) [Slides]

Aug 16, 2017
Why develop devTOX? Reduce prevalence of birth defects and decrease animal testing. Our approach represents a unique opportunity to screen compound safety using a human endpoint. devTOX quickPredict is a predictive, targeted biomarker assay. (devTOX Discovery, on the other hand, is a predictive, untargeted metabolomics assay.) Jessica Palmer presented this webinar in October 2016. If

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Jun 26

Prediction of Developmental Toxicity Potential Dictated by In Vivo Exposures with a Biomarker-Based Human Pluripotent Stem Cell Assay – Teratology Society 2017 [Slides]

Jun 26, 2017
Presented at the Teratology Society’s 57th Annual Meeting in Denver, Colorado in June 2017 by Stemina’s Associate Director of Toxicology, Jessica Palmer. Previous approaches for evaluating the accuracy of alternative test methods have been based on the classification of a chemical as either a positive or negative, with no other distinction. This method does not

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Jan 18

Exposure-Based Developmental Toxicity Prediction with the devTOX quickPredict Assay – Webinar (2017) [Recording, Slides]

Jan 18, 2017
The required in vivo preclinical models for developmental toxicity testing have varying degrees of concordance with human effects, having approximately 70% concordance to known human developmental toxins. Development and validation of alternative methods for assessing developmental toxicity potential, such as the devTOX quickPredict assay (devTOXqP) would decrease the time, expense, and use of vertebrate animals.

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Apr 11

Practical Application of a Human Stem Cell Assay for Developmental Toxicity Testing – SOT 2016 [Slides]

Apr 11, 2016
Presented at the Society of Toxicology’s 55th Annual Meeting held in New Orleans, March 2016. Please fill out the form to download the presentation slides:    

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