Nov 16

Human Pluripotent Stem Cell-Based Assay Predicts Developmental Toxicity Potential of ToxCast Chemicals – ACT 2016

Nov 16, 2017
Presented at the American College of Toxicology Annual Meeting, held in November 2016 in Baltimore, in collaboration with the United States Environmental Protection Agency (EPA). About the Poster The devTOX quickPredict platform is an in vitro human pluripotent stem cell-based assay used to assess a wide range of chemicals for potential developmental toxicity. To increase

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Nov 8

Development of a Targeted Biomarker Assay to Predict Cardiotoxicity Potential Using Metabolomics and Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes – ACT 2017

Nov 8, 2017
Presented at the American College of Toxicology’s 38th Annual Meeting in Palm Springs, California in November 2017 by Stemina’s Associate Director of Toxicology, Jessica Palmer. Cardiac safety is one of the leading causes of late-stage compound attrition in the pharmaceutical industry and accounts for 28% of the safety related withdrawals of FDA-approved drugs from the

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Aug 23

EU-ToxRisk Case Study: Developmental Toxicity Potency of Valproate Analogues in Human Pluripotent Stem Cell-Based Assay – WC-10 (2017)

Aug 23, 2017
Presented at the 10th World Congress on Alternatives and Animal Use in the Life Sciences in Seattle, August 2017, by Stemina’s Associate Director of Toxicology, Jessica Palmer. The development and use of alternative models of safety screening in place of animal models has been at the forefront of the toxicology field for over a decade;

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Mar 14

Comparative Retrospective Analysis of In Vivo and In Vitro Developmental Toxicity Predictions – SOT 2017

Mar 14, 2017
Presented at the Society of Toxicology’s Annual Meeting & ToxExpo in Baltimore, March 2017, by Stemina’s Associate Director of Toxicology, Jessica Palmer. Development and validation of in vitro models for developmental toxicity testing is essential for reducing the number of animals used toxicity testing. These assays have the potential to reduce or replace animal use in

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May 16

Evidence for Metabolomic Phenotypes Based on Analysis of Plasma from the Autism Phenome Project Cohort – IMFAR 2016

May 16, 2016
Presented at the International Meeting for Autism Research, May 2016, in Baltimore, Maryland. Metabolomics can identify predictive and actionable biomarker profiles from a child’s inherited biochemistry as well as the interactions of the gut microbiome with dietary and environmental factors that may contribute to ASD. Identification of metabolic profiles in children with ASD creates an opportunity to

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Apr 1

Combination of a Human Pluripotent Stem Cell and Zebrafish Assay to Predict The Developmental Toxicity of Chemicals – SOT 2016

Apr 1, 2016
Presented at the Society of Toxicology 55th Annual Meeting and ToxExpo, held March 2016, in New Orleans, Louisiana by Jessica Palmer, Associate Director of Toxicology. The primary alternative in vitro-ex vivo assays used to evaluate developmental toxicity potential are cellular models using pluripotent stem cells and embryo-based models. Multiple industries are employing these types of

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