Journal Publications

Aug 16

Toward Good Read-Across Practice (GRAP) Guidance

Aug 16, 2017
Grouping of substances and utilizing read-across of data within those groups represents an important data gap filling technique for chemical safety assessments. Categories/analogue groups are typically developed based on structural similarity and, increasingly often, also on mechanistic (biological) similarity. While read-across can play a key role in complying with legislation such as the European REACH

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Aug 16

Stem Cell-Based Methods for Identifying Developmental Toxicity Potential

Aug 16, 2017
There is an increasing need for reliable, high-throughput in vitro developmental toxicity screens in both the pharmaceutical and chemical industries. Establishing predictive human cell-based assays to aid in the early discovery-phase detection of potential developmental toxicants is strongly warranted as these tests could reduce product development time and costs. Stemina authors include Jessica Palmer, Bob

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Aug 16

A Human Induced Pluripotent Stem Cell-Based In Vitro Assay Predicts Developmental Toxicity Through a Retinoic Acid Receptor-Mediated Pathway for a Series of Related Retinoid Analogues

Aug 16, 2017
The relative developmental toxicity potency of a series of retinoid analogues was evaluated using a human induced pluripotent stem (iPS) cell assay that measures changes in the biomarkers ornithine and cystine. A Human Induced Pluripotent Stem Cell-Based In Vitro Assay Predicts Developmental Toxicity … [Requires paid access]

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Aug 16

Supporting Read-Across Using Biological Data

Aug 16, 2017
Read-across, i.e., filling toxicological data gaps by relating to similar chemicals for which test data are available, is usually done based on chemical similarity. Besides structure and physico-chemical properties, biological similarity based on biological data adds extra strength to this process. In the simplest case, chemically similar substances also show similar test results in relevant

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Aug 1

Establishment and Assessment of a New Human Embryonic Stem Cell-Based Biomarker Assay for Developmental Toxicity Screening

Aug 1, 2013
Birth Defects Research (Volume 98, Issue 4, August 2013, Pages 343-363) A metabolic biomarker-based in vitro assay utilizing human embryonic stem (hES) cells was developed to identify the concentration of test compounds that perturbs cellular metabolism in a manner indicative of teratogenicity. This assay is designed to aid the early discovery-phase detection of potential human

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