Combination of a Human Pluripotent Stem Cell and Zebrafish Assay to Predict The Developmental Toxicity of Chemicals [SOT 2016]
Presented at the Society of Toxicology 55th Annual Meeting and ToxExpo, held March 2016, in New Orleans, Louisiana by Jessica Palmer, Associate Director of Toxicology.
The primary alternative in vitro-ex vivo assays used to evaluate developmental toxicity potential are cellular models using pluripotent stem cells and embryo-based models. Multiple industries are employing these types of assays to screen for toxicity potential and enable selection and prioritization of the most promising chemicals for further development, effectively reducing the number animals required for developmental toxicity testing. Additionally, ongoing worldwide initiatives, such as Tox21 and ToxCast, are utilizing these inexpensive and high-throughput alternative models to screen thousands of chemicals currently in use for toxicity potential. Given the numerous complex processes involved in fetal development, evaluating chemicals in more than one alternative assay yields a more complete view of the chemical’s developmental toxicity potential.View PDF